Research Reviews

As a part of our initiative to make scientific research more accessible to families we present “Article Reviews” - a review of scientific research articles relevant to GIGYF1.

Click Here For More Reviews

Research Papers

Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (2003): Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. The Journal of biological chemistry. 278:31564–31573. 🔗
Chen G, Yu B, Tan S, Tan J, Jia X, et al. (2022): GIGYF1 disruption associates with autism and impaired IGF-1R signaling. J Clin Invest. 132(19):e159806. 🔗
Amaya Ramirez CC, Hubbe P, Mandel N, Bethune J (2018): 4EHP-independent repression of endogenous mRNAs by the RNA- binding protein GIGYF2. Nucleic acids research. 🔗
Peter D, Weber R, Sandmeir F, Wohlbold L, Helms S, Bawankar P, et al. (2017): GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes & development. 31:1147–1161. 🔗
Weber R, Chung MY, Keskeny C, Zinnall U, Landthaler M, Valkov E, et al. (2020): 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay. Cell Rep. 33:108262. 🔗
Ding Z, Huang G, Wang T, Duan W, Li H, et al. Genetic ablation of GIGYF1, associated with autism, causes behavioral and neurodevelopmental defects in zebrafish and mice. Biol Psychiatry. 2023 Mar 15;94(10):769–779. 🔗