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GIGYF1 related syndrome
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GIGYF1 Foundation
Home
About GIGYF1
GIGYF1 related syndrome
Genetics & Inheritance
Rare disease fact sheet
Who we are
Our vision & mission
Strategic Priorities
Meet our Team
Letter from Founder
Resources for Families
Join our Facebook Group
Patient Registry- Coming soon
Research & News
Donate
Home
Folder: About GIGYF1
Back
GIGYF1 related syndrome
Genetics & Inheritance
Rare disease fact sheet
Folder: Who we are
Back
Our vision & mission
Strategic Priorities
Meet our Team
Letter from Founder
Folder: Resources for Families
Back
Join our Facebook Group
Patient Registry- Coming soon
Research & News
Donate

Research

  • Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland KA, Smith RJ (2003): Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. The Journal of biological chemistry. 278:31564–31573. 🔗

  • Chen G, Yu B, Tan S, Tan J, Jia X, et al. (2022): GIGYF1 disruption associates with autism and impaired IGF-1R signaling. J Clin Invest. 132(19):e159806. 🔗

  • Amaya Ramirez CC, Hubbe P, Mandel N, Bethune J (2018): 4EHP-independent repression of endogenous mRNAs by the RNA- binding protein GIGYF2. Nucleic acids research. 🔗

  • Peter D, Weber R, Sandmeir F, Wohlbold L, Helms S, Bawankar P, et al. (2017): GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes & development. 31:1147–1161. 🔗

  • Weber R, Chung MY, Keskeny C, Zinnall U, Landthaler M, Valkov E, et al. (2020): 4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay. Cell Rep. 33:108262. 🔗

  • Ding Z, Huang G, Wang T, Duan W, Li H, et al. Genetic ablation of GIGYF1, associated with autism, causes behavioral and neurodevelopmental defects in zebrafish and mice. Biol Psychiatry. 2023 Mar 15;94(10):769–779. 🔗

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